InVivoSIM anti-human CD14 (Atibuclimab Biosimilar)
货号 #SIM0061
克隆号:
Atibuclimab
反应种属:
Human
￥2,448 - ￥84,656
产品详情
This non-therapeutic biosimilar antibody uses the same variable regions as the therapeutic antibody Atibuclimab, making it ideal for research use. Atibuclimab is a chimeric monoclonal antibody composed of murine variable regions and a human IgG4 Fc region. It targets CD14, a key pattern recognition receptor involved in the detection of pathogen-associated molecular patterns (PAMPs) as part of the innate immune response. CD14 functions as a co-receptor for bacterial lipopolysaccharide (LPS), forming a complex with TLR4 and MD-2 to initiate pro-inflammatory signaling in response to Gram-negative bacterial components. CD14 is highly expressed on monocytes and macrophages, and is less abundantly expressed on neutrophils. It exists in both membrane-bound (mCD14) and soluble (sCD14) forms. Engagement of CD14 by PAMPs such as LPS triggers a cascade of downstream events that result in the production of cytokines including TNF-α, IL-1β, and IL-6. Atibuclimab binds to CD14 and blocks its interaction with LPS, reducing activation of the TLR4 signaling pathway and limiting the inflammatory response. Atibuclimab has been investigated for the treatment of systemic inflammatory conditions, including sepsis, acute lung injury, and cytokine-mediated disorders. This biosimilar antibody is well-suited for studying CD14-mediated signaling, innate immunity, monocyte/macrophage activation, and mechanisms of anti-inflammatory intervention.参数
| 同种型 | Human IgG4, κ |
|---|---|
| 推荐稀释缓冲液 | InVivoPure pH 7.0 Dilution Buffer |
| 免疫原 | Human CD14 |
| Reported Applications | Functional assays Flow cytometry ELISA |
| 形式 | PBS, pH 7.0 Contains no stabilizers or preservatives |
| 内毒素 | <0.5EU/mg (<0.0005EU/μg) Determined by LAL gel clotting assay |
| 聚合 | <5% Determined by SEC |
| 纯化 | >95% Determined by SDS-PAGE |
| 无菌性 | 0.2 μM filtration |
| 生产 | Purified from cell culture supernatant in an animal-free facility |
| 提纯 | Protein A |
| 分子量 | 150 kDa |
| 小鼠病原体试验 | Mouse Norovirus: Negative Mouse Parvovirus: Negative Mouse Minute Virus: Negative Mouse Hepatitis Virus: Negative Reovirus Screen: Negative Lymphocytic Choriomeningitis virus: Negative Lactate Dehydrogenase-Elevating Virus: Negative Mouse Rotavirus: Negative Theiler's Murine Encephalomyelitis: Negative Ectromelia/Mousepox Virus: Negative Hantavirus: Negative Polyoma Virus: Negative Mouse Adenovirus: Negative Sendai Virus: Negative Mycoplasma Pulmonis: Negative Pneumonia Virus of Mice: Negative Mouse Cytomegalovirus: Negative K Virus: Negative |
| 保存 | The antibody solution should be stored at the stock concentration at 4°C. Do not freeze. |
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Recommended Dilution Buffer
InVivoPure pH 7.0 Dilution Buffer
